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KMID : 0369319920120030291
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Allergy
1992 Volume.12 No. 3 p.291 ~ p.302
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A Study of Maternal-fetal Transmission of Allergic Diseases
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편복양
김창휘/이동환/이상주/이임순/이권해/조태호
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Abstract
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Recognition of the importance of allergic diseases had ptompted an increased an increased interests in genetic, environmental, and dietary factors which encountered pre-, and postnatally and may trigger the development of allergy. Identifying
these
factors during the pregnancy and early infancy may give us some parameters to prevent and predict early developing atopic symptoms.
A total 203 pairs of pregnant women and their newborns were selected for our study. We have examined the relationship of total serum IgE levels and specific IgE antibody(s-IgE Ab) scores between mothers and newborns. There was no correlation in
total
IgE levels between mothers and newborns; however, the mothers with positive s-IgE Ab scores to egg white, milk, and soybean had higher mean total IgE levels compared to the negative groups(p<0.001). In the cases of high risk groups (maternal
IgE>>1.01IU), there was higher incidence of positive s-IgE Ab scores to egg white and/or mild than of low risk groups (p<0.001).
The incidence of positive s-IgE Ab to egg white and /or milk in the newborns was significantly higher in the group with positive s-IgE Ab to same food antigen in the mothers (p<0.001).
During the follow-up period for 6~12 months after birth, four infants developed 6 allergic symptoms: Three infants had positive family history of atopic diseases and one infant had high serum IgE levels which was also found in her mother´s All
four
cases had positive s-IgE Ab to egg white and/or mild.
In this study, we found that newborn´s total serum IgE levels were not correlated with mother´s but in high risk group, fetus can produce s-IgE Ab to certain antigens which might be transferred from mother via intrauterine transport during the
pregnancy. In addition, we also re-confirmed that family history was the most important factor to develop and predict atopic symptoms in infants.
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KEYWORD
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